Dr. Shahverdi writes about pain management after surgery

Acute pain following surgery known as the issue that most patients suffer from it; but chronic pain after surgery is a problem that has needed a little more attention.

Depending on the type of surgery, 10% to 68% of surgical patients may be suffering from chronic pain that 2% to 10% of them suffer from severe pain. There is no exact  definition of chronic pain after surgery, and also differences in diagnostic procedures and  questionnaires used for evaluation of pain after surgery, may explain the differences in prevalence rate in various studies. Currently it is accepted that duration of pain after surgery should be lasting at least two months after the operation time to make a trustworthy diagnosis. Risk factors of chronic pain After surgery divided into three periods: before surgery, during surgery and after surgery. Pathophysiological processes that occur after tissue damage indicate that acute pain may become persistent. Inflammation at the site of tissue damage creates a barrage

of afferent nociceptors activity that causes peripheral and central nervous system sensitization and creates functional changes in the peripheral nerves, spinal cord, higher routes pain center and the sympathetic nervous system It seems that specific receptor sites such as N-methyl-D-aspartate receptor is particularly important in chronic pain following acute injury and descending pathways pain control also probably the decisive factor in

chronic pain. In another systematic review it has been shown that administration of Gabapentin consumption before surgery cause more reduced pain after surgery compared to the control group and also may decrease the dose of opioids and side effects. Chronic pain after surgery often has a neuropathic component. Even in the early stages, it can be seen as a neuropathic pain after surgery. Therefore, drugs for treatment of chronic neuropathic pain are used as the adjuvant drug for pain ante surgery increasingly. It has been shown in numerous studies that some drugs such as Gabapentin and Pregabalin, not only can reduce the severity of acute pain after surgery and reduce the analgesic dose but also may contribute to  the prevention of chronic pain after surgery. In a metaanalysis of Clark and colleagues, it was found that the use of Gabapentin and Pregabalin improved the patient functional outcomes in long-term.

Various mechanisms have been suggested for these drugs, but it is still not entirely clear that what extent involve these mechanisms the analgesic effects of this drug, dose, metabolism and drug interactions, but now evidence-based data revealed that there is no report of the duration of optimum consumption time and need for further investigation.


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